![]() ![]() The Program, as well as the prices and the list of covered drugs, can be modified at any time without notice. The day supply is based upon the average dispensing patterns for the specific drug and strength. Discount percentages represent savings provided off of pharmacies’ retail prices for consumers who do not have a discount program and pay cash. *Average and up to savings percentages are based on all discounted prescriptions that were run through the WellRx program in 2020. This program is administered by Medical Security Card Company, LLC, Tucson, AZ. You may contact customer care anytime with questions or concerns, to cancel your registration, or to obtain further information. Cannot be used in conjunction with insurance. SYNTHROID (levothyroxine sodium) tablets, for oral use. Members are required to pay for all prescription purchases. This program does not make payments directly to pharmacies. The range of the discounts will vary depending on the type of prescription and the pharmacy chosen. Discounts are available exclusively through participating pharmacies. The pricing estimates given are based on the most recent information available and may change based on when you actually fill your prescription at the pharmacy.ÄISCOUNT ONLY - NOT INSURANCE. Volunteers with clinically significant allergies to food, medication, etc.Prescription prices may vary from pharmacy to pharmacy and are subject to change.Volunteers on a special diet in the last 28 days (eg vegetarian diet, etc.).Volunteers who do not avoid the intake of coffee, tea, grapefruit, cola and / or alcoholic beverages during the 48 h preceding the study.Volunteers who do not maintain the conditions of fasting and food intake in the pre-established schedules.Volunteers who must start a scheduled medical or pharmacological treatment outside the this Protocol.Positive beta-HCG test in female volunteers.Female volunteers who are breastfeeding during the study period.Abnormal results outside the reference values for thyroid function (T3, T4, TSH, anti-TPO antibodies).Clinically significant abnormal laboratory test results.Having donated blood within the 3 months prior to the start of the study.Having participated in another research study in the last 6 months.Hypersensitivity to Levothyroxine sodium or to excipients (from formulations to test).History of seizure disorders, depressive disorders, cardiovascular diseases, hematological, metabolic, vesicular or other, that the Principal Investigator judges clinically significant.Ingestion of other drugs the 2 weeks prior to the start of the study.It works by replacing thyroid hormone when the. History of drug or alcohol abuse in the last two years. Levothyroxine(Levothroid) generic Eltroxin (100 mcg) is a thyroid hormone, prescribed for hypothyroidism.History of liver disease, kidney disease or conditions of psychiatric origin.Sex: both (male and female, homogenously distributed).Healthy volunteers according to antecedents, clinical evaluation, biochemical tests and other complimentary tests.There will be two treatment sequences (AB, BA) and a 42 day washout between the two treatment periods. 80 healthy adults will be randomized to receive a single dose (6 x 100 mcg tablets = 600 mcg) of the test formulation of levothyroxine and reference formulation of levothyroxine separately in each treatment period. This will be a single-center, open-label, two-period, two-treatment, two-sequence, randomized, single-dose, crossover study. It will then evaluate the impact on drug product performance based on pharmacokinetic (PK) measures of total serum T4 and total serum T3 of the new formulation of levothyroxine (Test formulation) relative to the reference formulation from Merck (Reference formulation) Tecnoquimicas modified its Levothyroxine tablets formulation in order to comply with new pharmacopeial specifications. change in brand or formulation) can cause significant changes in serum thyroid stimulating hormone (TSH) concentrations, precise and accurate TSH control is critical to avoid potential adverse iatrogenic effects. Since small changes in levothyroxine administration (e.g. Levothyroxine is also endogenously produced in the body. Its physiologically active metabolite is tri-iodothyronine (T3). Levothyroxine (T4) is used to treat patients with hypothyroidism and may often result in lifelong therapy. Why Should I Register and Submit Results?. ![]()
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